rs2229992

A SNP in the APC gene on chromosome 5. Its most notable genotype is G;T: Familial Adenomatous Polyposis

Gene
APC
Location
Chr 5112,827,157 (GRCh38)
Highest magnitude
6.5Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;TMost notableBadFamilial Adenomatous PolyposisVery important · 6.50% of people
  2. T;TGoodcommon in clinvarTypical · 0.030% of people

On SNPedia: (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;T 0% T;T 30%
  • European ancestry (Utah)G;T 0% T;T 8%
  • Han Chinese (Beijing)G;T 0% T;T 10%
  • Japanese (Tokyo)G;T 0% T;T 5%
  • Yoruba (Nigeria)G;T 0% T;T 82%
  • African ancestry (Southwest US)G;T 0% T;T 53%
  • Chinese (Denver)G;T 0% T;T 12%
  • Gujarati IndianG;T 0% T;T 13%
  • Luhya (Kenya)G;T 0% T;T 63%
  • Mexican ancestry (Los Angeles)G;T 0% T;T 9%
  • Maasai (Kenya)G;T 0% T;T 58%
  • TuscanG;T 0% T;T 21%

Other APC SNPs

All APC SNPs

Source and license

Adapted from rs2229992 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.