rs2230782

A SNP in the NCOA3 gene on chromosome 20. Its most notable genotype is C;C: 0.45x reduced risk for breast cancer

Gene
NCOA3
Location
Chr 2047,636,144 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated0.45x reduced risk for breast cancerWorth knowing · 2.0<1% of people
  2. C;GNot ratedNo summary available.Typical · 0.09% of people
  3. G;GGoodcommon on affy axiom dataTypical · 0.090% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C <1% C;G 9% G;G 90%
  • European ancestry (Utah)C;C 2% C;G 23% G;G 75%
  • Han Chinese (Beijing)C;C 0% C;G 7% G;G 93%
  • Japanese (Tokyo)C;C 0% C;G 7% G;G 93%
  • Yoruba (Nigeria)C;C 0% C;G 0% G;G 100%

Conditions, medicines and genes

Other NCOA3 SNPs

All NCOA3 SNPs

Notes

From SNPedia

Notes

rs2230782, also known as Q586H, is a SNP in the nuclear receptor coactivator 3 NCOA3 gene; this gene is also known as SRC-3 or AIB1. A study of 1,218 familial BRCA1/2-mutation negative breast cancer cases and 1,509 matched controls strengthened a (previously reported) protective effect of rs2230782. The reported odds ratio for rs2230782(C;C) homozygotes is 0.45 (CI: 0.21-0.98).

Source and license

Adapted from rs2230782 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.