rs2231142(T;T)

Causes gout

Magnitude
3.5Important
Repute
Bad
Frequency
3%Average of 10 populations
On SNPedia
rs2231142(A;A)Minus strand
Gene
ABCG2

Frequency

Share of people with T;T in each HapMap population.

  • Japanese (Tokyo)10%
  • Han Chinese (Beijing)9%
  • Chinese (Denver)8%
  • Mexican ancestry (Los Angeles)5%
  • Tuscan1%
  • European ancestry (Utah)<1%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Gujarati Indian0%
  • Maasai (Kenya)0%

Other genotypes of rs2231142

  1. G;TBad1.74x increased gout risk; gefinitib takers 4x more susceptible to diarrheaWorth knowing · 2.123% of people
  2. G;GGoodnormalTypical · 0.073% of people

All about rs2231142

Notes

From SNPedia

At least 10% of all gout cases in whites are attributable to this causal variant. ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout. This variation influences uric acid concentrations and causes 53% reduced urate transport rates compared to wild-type. Reduced transport of chemotherapeutic agents by this mutation . Other reported effects include 4x higher risk of diarrhea when taking gefitinib and 2x effectiveness of rosuvastatin.

References

Source and license

Adapted from rs2231142(A;A) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.