rs2235375

A SNP in the IRF6 gene on chromosome 1. Its most notable genotype is G;G: common in clinvar

Gene
IRF6
Location
Chr 1209,792,242 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
40%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.036% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 36%
  • European ancestry (Utah)G;G 39%
  • Han Chinese (Beijing)G;G 17%
  • Japanese (Tokyo)G;G 13%
  • Yoruba (Nigeria)G;G 58%
  • African ancestry (Southwest US)G;G 40%
  • Chinese (Denver)G;G 15%
  • Gujarati IndianG;G 26%
  • Luhya (Kenya)G;G 66%
  • Mexican ancestry (Los Angeles)G;G 29%
  • Maasai (Kenya)G;G 44%
  • TuscanG;G 47%

Other IRF6 SNPs

All IRF6 SNPs

Notes

From SNPedia

Notes

Strong evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and nonsyndromic cleft lip with or without cleft palate, in an Italian population. Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis. Genetic variants in IRF6 and the risk of facial clefts: single-marker and haplotype-based analyses in a population-based case-control study of facial clefts in Norway. Genetic control of individual differences in gene-specific methylation in human brain.

Source and license

Adapted from rs2235375 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.