rs2241524

A SNP in the LILRA2 gene on chromosome 19. Its most notable genotype is G;G: normal

Gene
LILRA2
Location
Chr 1954,587,200 (GRCh38)
Highest magnitude
0.0Typical
Tested on
AncestryDNA
Minor allele frequency
10%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodnormalTypical · 0.074% of people
  2. A;GNot ratednormalTypical · 0.025% of people
  3. A;ANot rated~2x increased risk for lupus and MPATypical · 0.02% of people

SNPedia records rs2241524 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 74% A;G 25% A;A 2%
  • European ancestry (Utah)G;G 100% A;G 0% A;A 0%
  • Han Chinese (Beijing)G;G 50% A;G 48% A;A 2%
  • Japanese (Tokyo)G;G 51% A;G 44% A;A 5%
  • Yoruba (Nigeria)G;G 94% A;G 6% A;A 0%

Notes

From SNPedia

Notes

rs2241524 is a SNP in the LILRA2 gene that disrupts the splice acceptor site of intron 6. Case-control association studies on 273 Japanese patients with systemic lupus erythematosus (SLE) and 50 patients with microscopic polyangiitis (MPA) showed an association between the homozygous rs2241524(T;T) genotype (as oriented in dbSNP). For the association with SLE, the odds ratio was 1.82 (CI: 1.02-3.24, p=0.041) and for MPA, the odds ratio was 2.52 (CI: 1.07-5.96, p=0.049).

Source and license

Adapted from rs2241524 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.