rs2242944

A SNP on chromosome 21. Its most notable genotype is A;A: 0.7x lower odds of ankylosing spondylitis, according to 23andMe

Gene
None listed
Location
Chr 2139,093,252 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood0.7x lower odds of ankylosing spondylitis, according to 23andMeMinor · 1.028% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 28%
  • European ancestry (Utah)A;A 16%
  • Han Chinese (Beijing)A;A 16%
  • Japanese (Tokyo)A;A 11%
  • Yoruba (Nigeria)A;A 69%
  • African ancestry (Southwest US)A;A 52%
  • Chinese (Denver)A;A 12%
  • Gujarati IndianA;A 17%
  • Luhya (Kenya)A;A 48%
  • Mexican ancestry (Los Angeles)A;A 19%
  • Maasai (Kenya)A;A 35%
  • TuscanA;A 18%

Conditions, medicines and genes

Notes

From SNPedia

Notes

23andMe reports that the GG genotype at rs2242944 is associated with 1.4x higher odds of ankylosing spondylitis, and the AA genotype is associated with 0.7x lower odds. Association of the intergenic single-nucleotide polymorphism rs10865331 (2p15) with ankylosing spondylitis in a Spanish population.

A;A

23andMe reports that the GG genotype at rs2242944 is associated with 1.4x higher odds of ankylosing spondylitis, and the AA genotype is associated with 0.7x lower odds.

Source and license

Adapted from rs2242944 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.