rs2252586

A SNP on chromosome 7. Its most notable genotype is T;T: 1.4x higher risk for glioma development

Gene
None listed
Location
Chr 754,911,231 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.4x higher risk for glioma developmentMinor · 1.47% of people
  2. C;TBad1.2x higher risk for glioma developmentMinor · 1.228% of people

SNPedia records rs2252586 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 7% C;T 28%
  • European ancestry (Utah)T;T 7% C;T 40%
  • Han Chinese (Beijing)T;T 0% C;T 4%
  • Japanese (Tokyo)T;T 0% C;T 2%
  • Yoruba (Nigeria)T;T 10% C;T 39%
  • African ancestry (Southwest US)T;T 7% C;T 49%
  • Chinese (Denver)T;T <1% C;T 8%
  • Gujarati IndianT;T 4% C;T 18%
  • Luhya (Kenya)T;T 17% C;T 40%
  • Mexican ancestry (Los Angeles)T;T 5% C;T 36%
  • Maasai (Kenya)T;T 10% C;T 46%
  • TuscanT;T 15% C;T 28%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Associated with glioma risk. Genetic causes of glioma: new leads in the labyrinth.

Source and license

Adapted from rs2252586 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.