rs2270641

A SNP in the SLC18A1 gene on chromosome 8. Its most notable genotype is G;G: 3.7x higher risk for schizophrenia

Gene
SLC18A1
Location
Chr 820,180,955 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad3.7x higher risk for schizophreniaWorth knowing · 2.18% of people
  2. G;TNot rated?Typical · 0.033% of people
  3. T;TGoodnormalTypical · 0.059% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 8% G;T 33% T;T 59%
  • European ancestry (Utah)G;G 13% G;T 49% T;T 38%
  • Han Chinese (Beijing)G;G 8% G;T 34% T;T 58%
  • Japanese (Tokyo)G;G 13% G;T 43% T;T 43%
  • Yoruba (Nigeria)G;G <1% G;T 20% T;T 80%
  • African ancestry (Southwest US)G;G 2% G;T 30% T;T 68%
  • Chinese (Denver)G;G 7% G;T 28% T;T 65%
  • Gujarati IndianG;G 11% G;T 35% T;T 55%
  • Luhya (Kenya)G;G 2% G;T 21% T;T 77%
  • Mexican ancestry (Los Angeles)G;G 12% G;T 28% T;T 60%
  • Maasai (Kenya)G;G 4% G;T 30% T;T 66%
  • TuscanG;G 14% G;T 50% T;T 36%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2270641 is a SNP in the vesicular monoamine transporter SLC18A1 gene, encoding a Thr4Pro substitution. In dbSNP orientation, the (G) allele is associated with the Proline. A study of 62 patients with schizophrenia concluded that the frequency of rs2270641(G;G) homozygotes was significantly higher. The reported odds ratio was 3.74 (CI: 1.7-8.2, p=0.0006) in this population of European descent. Note: another SNP, rs56575139, marks the same genomic location as rs2270641.

Source and license

Adapted from rs2270641 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.