rs2270954
A SNP in the DCC gene on chromosome 18. Its most notable genotype is A;A: Possible increased susceptibility to schizophrenia
- Gene
- DCC
- Location
- Chr 1853,530,928 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 17%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 3%
- European ancestry (Utah)A;A 0%
- Han Chinese (Beijing)A;A 3%
- Japanese (Tokyo)A;A 5%
- Yoruba (Nigeria)A;A 3%
- African ancestry (Southwest US)A;A 5%
- Chinese (Denver)A;A 4%
- Gujarati IndianA;A 3%
- Luhya (Kenya)A;A 3%
- Mexican ancestry (Los Angeles)A;A 0%
- Maasai (Kenya)A;A 3%
- TuscanA;A 3%
Related
Notes
From SNPedia
Notes
The PMID above is interesting. It found an association between rs2270954 and schizophrenia. Patients were most likely to be homozygous for the minor allele. The study suggests that the DCC gene may contribute to individual genetic differences in susceptibility to schizophrenia. This SNP is located within the 3' untranslated region, an area known to contain a number of regulatory sequences that determine the stability and translation efficacy of mRNA.
A;A
A study found this SNP to be nominally associated with schizophrenia; patients were less likely to be heterozygous at this locus and more likely to be homozygous for the minor allele.
Source and license
Adapted from rs2270954 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.