rs2272783(A;G)

Low expression variant of FECH enzyme

Magnitude
2.2Worth knowing
Repute
Bad
Frequency
21%Average of 11 populations
On SNPedia
rs2272783(C;T)Minus strand
Gene
FECH

Frequency

Share of people with A;G in each HapMap population.

  • Japanese (Tokyo)51%
  • Mexican ancestry (Los Angeles)45%
  • Chinese (Denver)44%
  • Han Chinese (Beijing)41%
  • Gujarati Indian16%
  • European ancestry (Utah)11%
  • Luhya (Kenya)6%
  • Tuscan5%
  • African ancestry (Southwest US)4%
  • Maasai (Kenya)3%
  • Yoruba (Nigeria)2%

Other genotypes of rs2272783

  1. G;GMost notableBadlikely erythropoietic protoporphyria symptomsVery important · 4.04% of people
  2. A;AGoodcommon in clinvarTypical · 0.075% of people

All about rs2272783

Notes

From SNPedia

If your other FECH allele is normal, you are most likely asymptomatic. However, if you harbor this rs2272783(C;T) genotype AND your other FECH allele is actually nonfunctional, you are likely to have symptoms associated with Erythropoietic protoporphyria.

Source and license

Adapted from rs2272783(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.