rs2274224
A SNP in the PLCE1 gene on chromosome 10. Its most notable genotype is G;G: common in clinvar
- Gene
- PLCE1
- Location
- Chr 1094,279,840 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- Not on consumer chips
- Minor allele frequency
- 47%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 22%
- European ancestry (Utah)G;G 28%
- Han Chinese (Beijing)G;G 9%
- Japanese (Tokyo)G;G 41%
- Yoruba (Nigeria)G;G 10%
Related
Other PLCE1 SNPs
- rs2274223G;G1.9x increased risk for stomach & esophageal cancer (seen in Han Chinese)Worth knowing
- rs3203713A;Acommon in clinvarTypical
- rs3765524C;Ccommon in clinvarTypical
- rs11187837T;Tcommon in complete genomicsTypical
- rs11187870G;Gcommon in complete genomicsTypical
- rs17417407G;Gcommon in clinvarTypical
Source and license
Adapted from rs2274224 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.