rs2275913

A SNP in the IL17A gene on chromosome 6. Its most notable genotype is A;A: 3x increased gastric cancer risk. Increased risk of Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation

Gene
IL17A
Location
Chr 652,186,235 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad3x increased gastric cancer risk. Increased risk of Acute Graft-Versus-Host Disease after Unrelated Bone Marrow TransplantationTypical · 0.011% of people
  2. A;GNot rated1.4x increased gastric cancer risk. Increased risk of Acute Graft-Versus-Host Disease after Unrelated Bone Marrow TransplantationTypical · 0.035% of people
  3. G;GNot ratednormalTypical · 0.054% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 11% A;G 35% G;G 54%
  • European ancestry (Utah)A;A 12% A;G 46% G;G 42%
  • Han Chinese (Beijing)A;A 24% A;G 48% G;G 28%
  • Japanese (Tokyo)A;A 19% A;G 50% G;G 32%
  • Yoruba (Nigeria)A;A 0% A;G 12% G;G 88%
  • African ancestry (Southwest US)A;A 2% A;G 21% G;G 77%
  • Chinese (Denver)A;A 31% A;G 47% G;G 22%
  • Gujarati IndianA;A 19% A;G 42% G;G 40%
  • Luhya (Kenya)A;A 0% A;G 10% G;G 90%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 53% G;G 45%
  • Maasai (Kenya)A;A 1% A;G 9% G;G 90%
  • TuscanA;A 16% A;G 45% G;G 39%

Conditions, medicines and genes

Other IL17A SNPs

All IL17A SNPs

Notes

From SNPedia

Notes

rs2275913, also known as G-197A, is a SNP in the IL17A gene. A study of 811 Japanese subjects (524 without gastric cancer and 287 with gastric cancer) reported an odds ratio of 1.42 (CI: 1.09-1.85, p=0.01) for the rs2275913(A) allele, and 3.02 (CI: 1.86-4.91, p<0.0001) for the (A;A) genotype, with gastric cancer. This "A"-allele of this SNP is also functionally associated with acute Graft-Versus-Host Disease after unrelated bone marrow transplantation

Source and license

Adapted from rs2275913 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.