rs2279381

A SNP in the FABP7 gene on chromosome 6. Its most notable genotype is T;T: More fragmented sleep (no particular negative consequences)

Gene
FABP7
Location
Chr 6122,780,399 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodMore fragmented sleep (no particular negative consequences)Worth knowing · 2.5<1% of people
  2. C;TGoodSleep might be more fragmented (no particular negative consequences)Worth knowing · 2.05% of people
  3. C;CGoodcommon/normalTypical · 0.094% of people

SNPedia records rs2279381 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageT;T <1% C;T 5% C;C 94%
  • European ancestry (Utah)T;T 0% C;T 2% C;C 98%
  • Han Chinese (Beijing)T;T 0% C;T 16% C;C 84%
  • Japanese (Tokyo)T;T <1% C;T 9% C;C 90%
  • Yoruba (Nigeria)T;T 0% C;T 0% C;C 100%
  • Chinese (Denver)T;T <1% C;T 7% C;C 92%
  • Luhya (Kenya)T;T 0% C;T 3% C;C 97%
  • Mexican ancestry (Los Angeles)T;T 0% C;T 5% C;C 95%
  • TuscanT;T 0% C;T 1% C;C 99%

Other FABP7 SNPs

All FABP7 SNPs

Notes

From SNPedia

Notes

rs2279381, also known as c.502C>T, p.Thr61Met and T61M, represents a variant in the FABP7 gene on chromosome 6. A 2017 study of ~300 Japanese adult males monitored for a week found that the 10% carrying a variant rs2279381(A) allele exhibited more fragmented sleep than non-carriers. Specifically, although total amount of sleep was the same, carriers had sleep cycle bouts averaging 14 minutes compared to 18 minutes for non-carriers, and 27 bouts of sleep/wake vs 24 for non-carriers. No particular negative consequences were associated with the difference in sleep fragmentation.

C;T

see rs2279381

Source and license

Adapted from rs2279381 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.