rs2286812

A SNP in the RPL12P10 gene on chromosome 18. Its most notable genotype is T;T: ~4x higher risk for Fuchs' dystrophy, a corneal disorder

Gene
RPL12P10
Location
Chr 1856,050,233 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommonTypical · 0.081% of people
  2. C;TBad~2x higher risk for Fuchs' dystrophy, a corneal disorderMinor · 1.518% of people
  3. T;TMost notableBad~4x higher risk for Fuchs' dystrophy, a corneal disorderWorth knowing · 2.01% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 81% C;T 18% T;T 1%
  • European ancestry (Utah)C;C 80% C;T 18% T;T 2%
  • Han Chinese (Beijing)C;C 75% C;T 24% T;T 2%
  • Japanese (Tokyo)C;C 74% C;T 25% T;T 2%
  • Yoruba (Nigeria)C;C 93% C;T 6% T;T <1%
  • African ancestry (Southwest US)C;C 89% C;T 9% T;T 2%
  • Chinese (Denver)C;C 83% C;T 16% T;T 1%
  • Gujarati IndianC;C 57% C;T 40% T;T 3%
  • Luhya (Kenya)C;C 92% C;T 8% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 77% C;T 21% T;T 2%
  • Maasai (Kenya)C;C 92% C;T 8% T;T 0%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2286812 is a SNP in the transcription factor 4 TCF4 gene. It is one of several TCF4 SNPs reported to be independently associated with Fuchs' dystrophy.

Source and license

Adapted from rs2286812 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.