rs2292305

A SNP in the THBS1 gene on chromosome 15. Its most notable genotype is A;A: common in clinvar

Gene
THBS1
Location
Chr 1539,588,621 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
25%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in clinvarTypical · 0.051% of people

SNPedia records rs2292305 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 51%
  • European ancestry (Utah)A;A 81%
  • Han Chinese (Beijing)A;A 46%
  • Japanese (Tokyo)A;A 36%
  • Yoruba (Nigeria)A;A 29%
  • African ancestry (Southwest US)A;A 30%
  • Chinese (Denver)A;A 47%
  • Gujarati IndianA;A 64%
  • Luhya (Kenya)A;A 37%
  • Mexican ancestry (Los Angeles)A;A 83%
  • Maasai (Kenya)A;A 37%
  • TuscanA;A 75%

Other THBS1 SNPs

All THBS1 SNPs

Notes

From SNPedia

Notes

Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study. Association of thrombospondin 1 gene with schizophrenia in Korean population.

Source and license

Adapted from rs2292305 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.