rs2292813

A SNP in the SLC25A12 gene on chromosome 2. Its most notable genotype is C;T: decreased risk of autism

Gene
SLC25A12
Location
Chr 2171,787,719 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
AncestryDNA
Minor allele frequency
18%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadnormalTypical · 0.068% of people
  2. C;TMost notableGooddecreased risk of autismWorth knowing · 2.025% of people
  3. T;TGooddecreased risk of autismWorth knowing · 2.07% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 68% C;T 25% T;T 7%
  • European ancestry (Utah)C;C 89% C;T 11% T;T <1%
  • Han Chinese (Beijing)C;C 82% C;T 16% T;T 2%
  • Japanese (Tokyo)C;C 83% C;T 16% T;T <1%
  • Yoruba (Nigeria)C;C 35% C;T 49% T;T 16%
  • African ancestry (Southwest US)C;C 47% C;T 35% T;T 18%
  • Chinese (Denver)C;C 84% C;T 16% T;T <1%
  • Gujarati IndianC;C 79% C;T 20% T;T 1%
  • Luhya (Kenya)C;C 36% C;T 46% T;T 19%
  • Mexican ancestry (Los Angeles)C;C 69% C;T 19% T;T 12%
  • Maasai (Kenya)C;C 60% C;T 35% T;T 5%
  • TuscanC;C 89% C;T 11% T;T 0%

Other SLC25A12 SNPs

All SLC25A12 SNPs

Notes

From SNPedia

Notes

Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism. Mitochondrial aspartate/glutamate carrier SLC25A12 gene is associated with autism. Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk.

Source and license

Adapted from rs2292813 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.