rs2294008

A SNP in the PSCA gene on chromosome 8. Its most notable genotype is T;T: increased risk of gastric and bladder cancer

Gene
PSCA
Location
Chr 8142,680,513 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodlower risk of gastric and bladder cancerMinor · 1.433% of people
  2. T;TMost notableBadincreased risk of gastric and bladder cancerWorth knowing · 2.119% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 33% T;T 19%
  • European ancestry (Utah)C;C 33% T;T 17%
  • Han Chinese (Beijing)C;C 49% T;T 7%
  • Japanese (Tokyo)C;C 14% T;T 33%
  • Yoruba (Nigeria)C;C 58% T;T 7%
  • African ancestry (Southwest US)C;C 26% T;T 19%
  • Chinese (Denver)C;C 45% T;T 8%
  • Gujarati IndianC;C 24% T;T 23%
  • Luhya (Kenya)C;C 32% T;T 17%
  • Mexican ancestry (Los Angeles)C;C 19% T;T 31%
  • Maasai (Kenya)C;C 31% T;T 30%
  • TuscanC;C 32% T;T 16%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2976392 and diffuse-type gastric cancer (allele-specific odds ratio (OR) = 1.62, 95% CI = 1.38-1.89, P = 1.11 x 10(-9)). Substitution of the C allele with the risk allele T at a SNP in the first exon (rs2294008, which has r(2) = 0.995, D' = 0.999 with rs2976392) reduces transcriptional activity of an upstream fragment of the gene

Source and license

Adapted from rs2294008 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.