rs2297480

A SNP in the FDPS gene on chromosome 1. Its most notable genotype is T;T: normal

Gene
FDPS
Location
Chr 1155,309,691 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
42%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodnormalTypical · 0.038% of people
  2. G;TNot ratednormalTypical · 0.042% of people
  3. G;GNot ratedreduced response to anti-osteoporosis drugsTypical · 0.020% of people

SNPedia records rs2297480 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 38% G;T 42% G;G 20%
  • European ancestry (Utah)T;T 51% G;T 38% G;G 11%
  • Han Chinese (Beijing)T;T 4% G;T 40% G;G 55%
  • Japanese (Tokyo)T;T 7% G;T 38% G;G 55%
  • Yoruba (Nigeria)T;T 50% G;T 48% G;G 3%
  • African ancestry (Southwest US)T;T 39% G;T 47% G;G 14%
  • Chinese (Denver)T;T 10% G;T 44% G;G 46%
  • Gujarati IndianT;T 54% G;T 41% G;G 6%
  • Luhya (Kenya)T;T 48% G;T 43% G;G 9%
  • Mexican ancestry (Los Angeles)T;T 41% G;T 47% G;G 12%
  • Maasai (Kenya)T;T 51% G;T 44% G;G 5%
  • TuscanT;T 60% G;T 35% G;G 5%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2297480 is a SNP in the FDPS gene, which encodes an enzyme in the mevalonate pathway and therefore might alter the response to amino-bisphonate (drug) treatment of postmenopausal osteoporosis. A study of 234 Danish postmenopausal women treated for at least 2 years with amino-bisphonates concluded that rs2297480(C;C) homozygotes do not respond as successfully as (A;A) or (A;C) genotypes.

Source and license

Adapted from rs2297480 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.