rs2304016
A SNP in the SCN2A gene on chromosome 2. Its most notable genotype is A;A: common in complete genomics
- Gene
- SCN2A
- Location
- Chr 2165,311,993 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 3%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 7 HapMap populations.
- AverageA;A 92%
- European ancestry (Utah)A;A 97%
- Han Chinese (Beijing)A;A 69%
- Japanese (Tokyo)A;A 82%
- Yoruba (Nigeria)A;A 99%
- African ancestry (Southwest US)A;A 98%
- Gujarati IndianA;A 99%
- Luhya (Kenya)A;A 97%
Related
Other SCN2A SNPs
- rs794727152A;GInfantile spasms; early-onset epileptic encephalopathiesVery important
- rs796053137A;GComplex pediatric neurologic issues including seizures; see discussionVery important
- rs387906686C;TEarly infantile epileptic encephalopathy and also benign infantile spasmsVery important
- rs794727444A;GEarly infantile epileptic encephalopathy and also benign infantile spasmsVery important
- rs121917749C;TBenign familial neonatal-infantile seizuresVery important
- rs121917750C;GBenign familial neonatal-infantile seizuresVery important
- rs17183814G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs2304016 (IVS7-32A>G) is a SNP within the SCN2A (sodium channel, voltage-gated, type II, alpha subunit). among 471 Chinese epilepsy patients (of which 272 were drug responsive and 199 drug resistant), A-allele carriers associated with resistance to anti-epileptic drugs (OR 2.1, 95% CI 1.2-3.7, p=0.007), haplotypes containing A-alleles were also associated w/ drug resistance
Source and license
Adapted from rs2304016 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.