rs2305795

A SNP in the EIF3G gene on chromosome 19. Its most notable genotype is A;A: 1.64x higher risk of narcolepsy compared to (G;G) genotype

Gene
EIF3G
Location
Chr 1910,115,376 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.64x higher risk of narcolepsy compared to (G;G) genotypeWorth knowing · 2.039% of people
  2. A;GBad1.28x higher risk of narcolepsy compared to (G;G) genotypeWorth knowing · 2.047% of people
  3. G;GGoodnormal risk of narcolepsyTypical · 0.014% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 39% A;G 47% G;G 14%
  • European ancestry (Utah)A;A 33% A;G 47% G;G 20%
  • Han Chinese (Beijing)A;A 45% A;G 47% G;G 9%
  • Japanese (Tokyo)A;A 43% A;G 49% G;G 9%
  • Yoruba (Nigeria)A;A 31% A;G 50% G;G 19%
  • African ancestry (Southwest US)A;A 40% A;G 49% G;G 11%
  • Chinese (Denver)A;A 47% A;G 45% G;G 8%
  • Gujarati IndianA;A 39% A;G 40% G;G 22%
  • Luhya (Kenya)A;A 46% A;G 48% G;G 6%
  • Mexican ancestry (Los Angeles)A;A 45% A;G 47% G;G 9%
  • Maasai (Kenya)A;A 33% A;G 42% G;G 24%
  • TuscanA;A 33% A;G 55% G;G 12%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Common variants in P2RY11 are associated with narcolepsy. Found that rs2305795 G allele appears to lower the risk of narcolepsy. This SNP is also in the intronal area of the EIF3G gene.

Source and license

Adapted from rs2305795 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.