rs2351299

A SNP in the GABRB1 gene on chromosome 4. Its most notable genotype is G;G: normal risk of autism

Gene
GABRB1
Location
Chr 447,141,348 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormal risk of autismMinor · 1.059% of people
  2. G;TGoodpossible reduced risk of AutismMinor · 1.034% of people
  3. T;TGoodpossible reduced risk of autismMinor · 1.07% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 59% G;T 34% T;T 7%
  • European ancestry (Utah)G;G 70% G;T 27% T;T 3%
  • Han Chinese (Beijing)G;G 40% G;T 46% T;T 15%
  • Japanese (Tokyo)G;G 44% G;T 51% T;T 5%
  • Yoruba (Nigeria)G;G 48% G;T 40% T;T 12%
  • African ancestry (Southwest US)G;G 58% G;T 28% T;T 14%
  • Chinese (Denver)G;G 47% G;T 42% T;T 11%
  • Gujarati IndianG;G 65% G;T 33% T;T 2%
  • Luhya (Kenya)G;G 62% G;T 33% T;T 6%
  • Mexican ancestry (Los Angeles)G;G 75% G;T 23% T;T 2%
  • Maasai (Kenya)G;G 77% G;T 23% T;T 0%
  • TuscanG;G 66% G;T 30% T;T 4%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Investigation of autism and GABA receptor subunit genes in multiple ethnic groups.

T;T

Possible reduced risk of autism.ncbi.nlm.nih.gov

Source and license

Adapted from rs2351299 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.