rs235326
A SNP in the ITGB2 gene on chromosome 21. Its most notable genotype is A;A: common in clinvar
- Gene
- ITGB2
- Location
- Chr 2144,891,898 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 23%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs235326 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 7%
- European ancestry (Utah)A;A 9%
- Han Chinese (Beijing)A;A 7%
- Japanese (Tokyo)A;A 9%
- Yoruba (Nigeria)A;A 0%
- African ancestry (Southwest US)A;A 4%
- Chinese (Denver)A;A 4%
- Gujarati IndianA;A 14%
- Luhya (Kenya)A;A 0%
- Mexican ancestry (Los Angeles)A;A 19%
- Maasai (Kenya)A;A 0%
- TuscanA;A 15%
Related
Notes
From SNPedia
Notes
651 people of Japanese ethnicity, of which 274 were Japanese Americans living in Hawaii, and the remaining 377 were native Japanese. In the Japanese-American population, the risk of obesity was found to be 3.29-fold higher (a 95% confidence interval of 1.25-8.67, P = 0.02) in TT homozygotes than in C carriers. associated with obesity in Japanese living in the United States whose diet has become "westernized."
Source and license
Adapted from rs235326 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.