rs237025

A SNP in the SUMO4 gene on chromosome 6. Its most notable genotype is A;A: no credible risk

Gene
SUMO4
Location
Chr 6149,400,554 (GRCh38)
Highest magnitude
0.5Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
37%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.012% of people
  2. A;GNot ratedNo summary available.Typical · 0.040% of people
  3. A;AMost notableNot ratedno credible riskTypical · 0.548% of people

SNPedia records rs237025 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 12% A;G 40% A;A 48%
  • European ancestry (Utah)G;G 27% A;G 45% A;A 27%
  • Han Chinese (Beijing)G;G 7% A;G 41% A;A 52%
  • Japanese (Tokyo)G;G 8% A;G 43% A;A 50%
  • Yoruba (Nigeria)G;G 10% A;G 34% A;A 56%
  • African ancestry (Southwest US)G;G 7% A;G 23% A;A 70%
  • Chinese (Denver)G;G 6% A;G 40% A;A 53%
  • Gujarati IndianG;G 14% A;G 59% A;A 27%
  • Luhya (Kenya)G;G 3% A;G 23% A;A 75%
  • Mexican ancestry (Los Angeles)G;G 14% A;G 57% A;A 29%
  • Maasai (Kenya)G;G 7% A;G 31% A;A 62%
  • TuscanG;G 33% A;G 42% A;A 25%

Notes

From SNPedia

Show notes, about 320 words

suggested the contribution of rs237025 to type-1 diabetes, however in this failed to replicate. This SNP is also known as Met55Val, M55V, or A163G. This was the first SNP in SNPedia. The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population. SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris. Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm. Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15. Case-control association analysis of rheumatoid arthritis with candidate genes using related cases. Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests. Classification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests. Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. Small ubiquitin-like modifier 4 (SUMO4) polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome in the Chinese Han population. Overview of the Rapid Response data. The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

Source and license

Adapted from rs237025 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.