rs2398162

A SNP in the NR2F2-AS1 gene on chromosome 15. Its most notable genotype is A;A: 1.3x risk

Gene
NR2F2-AS1
Location
Chr 1596,287,321 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.3x riskTypical · 0.055% of people
  2. A;GNot ratednormalTypical · 0.030% of people
  3. G;GNot ratednormalTypical · 0.014% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 55% A;G 30% G;G 14%
  • European ancestry (Utah)A;A 58% A;G 36% G;G 5%
  • Han Chinese (Beijing)A;A 15% A;G 44% G;G 41%
  • Japanese (Tokyo)A;A 17% A;G 52% G;G 31%
  • Yoruba (Nigeria)A;A 88% A;G 10% G;G 1%
  • African ancestry (Southwest US)A;A 77% A;G 23% G;G 0%
  • Chinese (Denver)A;A 10% A;G 37% G;G 53%
  • Gujarati IndianA;A 48% A;G 42% G;G 11%
  • Luhya (Kenya)A;A 92% A;G 8% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 47% A;G 41% G;G 12%
  • Maasai (Kenya)A;A 88% A;G 12% G;G <1%
  • TuscanA;A 69% A;G 29% G;G 2%

Conditions, medicines and genes

Other NR2F2-AS1 SNPs

All NR2F2-AS1 SNPs

Notes

From SNPedia

Notes

rs2398162 has been reported in a large study to be associated with high blood pressure. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 0.97 (CI 0.76-1.25), and for homozygotes, 1.31 (CI 1.03-1.67).

Source and license

Adapted from rs2398162 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.