rs2472297

A SNP on chromosome 15. Its most notable genotype is C;T: Associated with (slightly) increased coffee consumption

Gene
None listed
Location
Chr 1574,735,539 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
10%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon on affy axiom dataTypical · 0.087% of people
  2. C;TMost notableNot ratedAssociated with (slightly) increased coffee consumptionMinor · 1.211% of people
  3. T;TNot ratedAssociated with (slightly) increased coffee consumptionMinor · 1.21% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageC;C 87% C;T 11% T;T 1%
  • European ancestry (Utah)C;C 56% C;T 39% T;T 5%
  • Han Chinese (Beijing)C;C 99% C;T <1% T;T 0%
  • Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
  • Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%
  • African ancestry (Southwest US)C;C 84% C;T 16% T;T 0%
  • Gujarati IndianC;C 95% C;T 5% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 81% C;T 16% T;T 3%
  • TuscanC;C 83% C;T 16% T;T 1%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2472297 is a SNP located between the CYP1A1 and CYP1A2 genes on ch 15q24. A meta-analysis of four GWAS studies of coffee consumption among a total of ~8,000 coffee drinkers of European ancestry found that the rs2472297(T) was strongly associated with increased consumption (p = 5.4 x 10e-14). The estimated effect was an increase of 0.2 cups a day per allele for both this SNP and one other (rs6968865).

Source and license

Adapted from rs2472297 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.