rs2494732

A SNP in the AKT1 gene on chromosome 14. Its most notable genotype is C;C: greater odds of cannabis-associated psychosis

Gene
AKT1
Location
Chr 14104,772,855 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadgreater odds of cannabis-associated psychosisWorth knowing · 2.1
  2. C;TBadslightly greater risk of temporary paranoia when toking (pot)Minor · 1.5
  3. T;TGoodlower odds of psychosisMinor · 1.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 360 words

rs2494732 is a SNP in the AKT1 gene, encoding one of three serine/threonine-protein kinases regulating numerous processes such as cell survival, growth and angiogenesis. Medical conditions that may be linked to the rarer (minor) rs2494732(C) allele include drug response, schizophrenia, and drug-related psychoses, in particular, cannabis-related psychosis. A study of 442 healthy, once-a-month cannabis users between the ages of 16-23 to see if AKT1 variants influenced acute psychosis response concluded that the number of rs2494732(C) alleles predicted (p = 0.015) acute (i.e. temporary) psychotic response to cannabis. Basically, the more copies someone had of this SNP, the more likely they were to have mind-altering symptoms while stoned. Other factors studied, including gender, ethnicity, and years of cannabis use, did not predict whether they would have these (transient) symptoms. Note that this side-effect (psychosis or paranoia) was infrequent in an absolute sense regardless of genotype. A case-control study of 489 first-episode psychosis patients concluded that while rs2494732 was not associated with an increased risk of a psychotic disorder, with lifetime cannabis use, or with frequency of use, there was a significant association between psychosis and cannabis use. rs2494732(C;C) individuals with a history of cannabis use had an increased likelihood of a psychotic disorder (odds ratio 2.18, CI: 1.1 - 4.3) when compared with users who were (T;T) carriers. The interaction between the rs2494732 genotype and frequency of use was also somewhat significant (likelihood ratio = 13.39; p = .010). Among daily users, (C;C) carriers had a 7x increase in the odds of psychosis compared with (T;T) carriers (odds ratio 7.23, CI: 1.37 - 38.12). among (likely Japanese) 120 first-episode neuroleptic-naive schizophrenics treated with risperidone genotyped for 30 variants in misc. dopamine and serotonin (receptors and otherwise) two SNPs in DRD2 (rs1799989 and rs1800497) and two SNPs in AKT1 (rs3803300 and rs2494732) were significant predictors of treatment response to risperidone The ancestral allele is C in the dbSNP database.

C;T

see discussion at rs2494732

Source and license

Adapted from rs2494732 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.