rs2515475
A SNP in the ANGPT2 gene on chromosome 8. Its most notable genotype is C;C: normal
- Gene
- ANGPT2
- Location
- Chr 86,530,918 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 16%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableNot ratednormal
- C;TBad1.27x increased ARDS risk in critically ill patients
- T;TBad1.27x increased ARDS risk in critically ill patients
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 67% C;T 27% T;T 6%
- European ancestry (Utah)C;C 73% C;T 26% T;T 2%
- Han Chinese (Beijing)C;C 93% C;T 7% T;T 0%
- Japanese (Tokyo)C;C 88% C;T 11% T;T 2%
- Yoruba (Nigeria)C;C 25% C;T 56% T;T 19%
- African ancestry (Southwest US)C;C 49% C;T 37% T;T 14%
- Chinese (Denver)C;C 95% C;T 5% T;T 0%
- Gujarati IndianC;C 73% C;T 26% T;T 1%
- Luhya (Kenya)C;C 45% C;T 43% T;T 12%
- Mexican ancestry (Los Angeles)C;C 79% C;T 21% T;T 0%
- Maasai (Kenya)C;C 39% C;T 46% T;T 16%
- TuscanC;C 78% C;T 22% T;T 0%
Notes
From SNPedia
Notes
rs2515475 is a SNP in the angiopoietin 2 ANGPT2 gene. A study of 1,529 critically ill patients with risk factors for acute respiratory distress syndrome (ARDS), of whom 449 did develop ARDS and 1,080 did not, found that carriers of a rs2515475(T) allele were at higher risk for ARDS (adjusted odds ratio 1.28, p = 0.042). This risk was higher (odds ratio 1.79) in patients with extrapulmonary injuries.
Source and license
Adapted from rs2515475 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.