rs2518224

A SNP in the GRIK2 gene on chromosome 6. Its most notable genotype is A;A: normal

Gene
GRIK2
Location
Chr 6101,458,776 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.091% of people
  2. A;CNot ratednormalTypical · 0.09% of people
  3. C;CBad8.2x higher risk of suicidal thoughts when taking citalopramTypical · 0.0<1% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 91% A;C 9% C;C <1%
  • European ancestry (Utah)A;A 73% A;C 27% C;C <1%
  • Han Chinese (Beijing)A;A 100% A;C 0% C;C 0%
  • Japanese (Tokyo)A;A 100% A;C 0% C;C 0%
  • Yoruba (Nigeria)A;A 95% A;C 5% C;C 0%
  • African ancestry (Southwest US)A;A 97% A;C 4% C;C 0%
  • Gujarati IndianA;A 94% A;C 6% C;C 0%
  • Luhya (Kenya)A;A 96% A;C 5% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 83% A;C 16% C;C 2%
  • Maasai (Kenya)A;A 86% A;C 14% C;C 0%
  • TuscanA;A 83% A;C 14% C;C 3%

Conditions, medicines and genes

Notes

From SNPedia

Notes

This SNP, located in an intron of the GRIK2 gene, has been linked in one study to increased thoughts of suicide in patients using the anti-depressant drug citalopram. The risk is only seen for individuals carrying two rs2518224(C) alleles, i.e. the rs2518224(C;C) homozygotes. The odds ratio for these individuals is 8.2. If the individual also has at least one rs4825476(G) allele, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6).

Source and license

Adapted from rs2518224 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.