rs2523608
A SNP in the HLA-B gene on chromosome 6. Its most notable genotype is G;G: common in clinvar
- Gene
- HLA-B
- Location
- Chr 631,354,782 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 42%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2523608 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 17%
- European ancestry (Utah)G;G 20%
- Han Chinese (Beijing)G;G 33%
- Japanese (Tokyo)G;G 12%
- Yoruba (Nigeria)G;G 12%
- African ancestry (Southwest US)G;G 5%
- Chinese (Denver)G;G 44%
- Gujarati IndianG;G 11%
- Luhya (Kenya)G;G 10%
- Mexican ancestry (Los Angeles)G;G 21%
- Maasai (Kenya)G;G 10%
- TuscanG;G 12%
Related
Other HLA-B SNPs
Genosets
- Gs187HLA-B*5801 homozygosity is possible. too common to be usefulWorth knowing
- Gs186HLA-B*5801 heterozygosity is possible, unfortunately this is just too common to be usefulMinor
Genosets combine several genotypes. Twofold checks them in your report.
Source and license
Adapted from rs2523608 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.