rs2546890

A SNP in the LOC285626 gene on chromosome 5. Its most notable genotype is A;A: Higher risk of multiple sclerosis

Gene
LOC285626
Location
Chr 5159,332,892 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadHigher risk of multiple sclerosisMinor · 1.019% of people
  2. A;GBadHigher risk of multiple sclerosisMinor · 1.047% of people
  3. G;GGoodLower risk of multiple sclerosisMinor · 1.035% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 19% A;G 47% G;G 35%
  • European ancestry (Utah)A;A 29% A;G 54% G;G 17%
  • Han Chinese (Beijing)A;A 24% A;G 47% G;G 29%
  • Japanese (Tokyo)A;A 22% A;G 40% G;G 38%
  • Yoruba (Nigeria)A;A 8% A;G 50% G;G 42%
  • African ancestry (Southwest US)A;A 21% A;G 51% G;G 28%
  • Chinese (Denver)A;A 12% A;G 58% G;G 30%
  • Gujarati IndianA;A 36% A;G 48% G;G 17%
  • Luhya (Kenya)A;A 9% A;G 35% G;G 56%
  • Mexican ancestry (Los Angeles)A;A 12% A;G 40% G;G 48%
  • Maasai (Kenya)A;A 12% A;G 51% G;G 38%
  • TuscanA;A 19% A;G 44% G;G 37%

Conditions, medicines and genes

Other LOC285626 SNPs

All LOC285626 SNPs

Notes

From SNPedia

Notes

23andMe blog multiple sclerosis rs2546890 IL12B G 0.87

Source and license

Adapted from rs2546890 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.