rs2609653

A SNP on chromosome 8. Its most notable genotype is A;A.

Gene
None listed
Location
Chr 834,379,474 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. C;CNot rated3.6x riskTypical · 0.0<1% of people
  3. C;TNot rated1.5x riskTypical · 0.08% of people
  4. T;TGoodnormalTypical · 0.091% of people

On SNPedia: (A;A), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 0% C;C <1% C;T 8% T;T 91%
  • European ancestry (Utah)A;A 0% C;C <1% C;T 9% T;T 90%
  • Han Chinese (Beijing)A;A 0% C;C 0% C;T 10% T;T 90%
  • Japanese (Tokyo)A;A 0% C;C 0% C;T 7% T;T 93%
  • Yoruba (Nigeria)A;A 0% C;C <1% C;T 13% T;T 86%
  • African ancestry (Southwest US)A;A 0% C;C 2% C;T 7% T;T 91%
  • Chinese (Denver)A;A 0% C;C 0% C;T 16% T;T 84%
  • Gujarati IndianA;A 0% C;C 0% C;T 2% T;T 98%
  • Luhya (Kenya)A;A 0% C;C 0% C;T 8% T;T 92%
  • Mexican ancestry (Los Angeles)A;A 0% C;C 0% C;T 3% T;T 97%
  • Maasai (Kenya)A;A 0% C;C 0% C;T 8% T;T 92%
  • TuscanA;A 0% C;C 0% C;T 8% T;T 92%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs2609653 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.43 (CI 1.19-1.71), and for homozygotes, 3.62 (CI 1.26-10.44).

Source and license

Adapted from rs2609653 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.