rs2619522

A SNP in the DTNBP1 gene on chromosome 6. Its most notable genotype is C;C: associated with lower attention capacity but also a decrease in positive and paranoid schizotypy scores

Gene
DTNBP1
Location
Chr 615,653,418 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableBadassociated with lower attention capacity but also a decrease in positive and paranoid schizotypy scoresWorth knowing · 2.09% of people
  2. A;AGoodNo summary available.Typical · 0.059% of people

SNPedia records rs2619522 on the minus strand: (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 9% A;A 59%
  • European ancestry (Utah)C;C 4% A;A 71%
  • Han Chinese (Beijing)C;C <1% A;A 84%
  • Japanese (Tokyo)C;C <1% A;A 89%
  • Yoruba (Nigeria)C;C 14% A;A 32%
  • African ancestry (Southwest US)C;C 18% A;A 33%
  • Chinese (Denver)C;C <1% A;A 82%
  • Gujarati IndianC;C 6% A;A 66%
  • Luhya (Kenya)C;C 22% A;A 36%
  • Mexican ancestry (Los Angeles)C;C 3% A;A 66%
  • Maasai (Kenya)C;C 24% A;A 24%
  • TuscanC;C 3% A;A 64%

Conditions, medicines and genes

Other DTNBP1 SNPs

All DTNBP1 SNPs

Notes

From SNPedia

Notes

g2b2mh blog In a population of healthy individuals, those that carry common variants (such as rs760761, rs1018381, rs2619522) located in the dysbindin (DTNBP1) gene, a risk factor for schizophrenia, show minor cognitive impairments such as decreased attentional capacity, worse performance on memory tasks, and alterations in schizotypal beliefs and experiences.

Source and license

Adapted from rs2619522 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.