rs2648875

A SNP in the PVT1 gene on chromosome 8. Its most notable genotype is A;A: 8.82x increased risk of ESRD in diabetes type II patients

Gene
PVT1
Location
Chr 8128,059,915 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
41%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad8.82x increased risk of ESRD in diabetes type II patientsTypical · 0.024% of people
  2. A;GBad2.97x increased risk of ESRD in diabetes type II patientsTypical · 0.046% of people
  3. G;GGoodnormalTypical · 0.030% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 24% A;G 46% G;G 30%
  • European ancestry (Utah)A;A 11% A;G 36% G;G 53%
  • Han Chinese (Beijing)A;A 35% A;G 42% G;G 23%
  • Japanese (Tokyo)A;A 37% A;G 55% G;G 9%
  • Yoruba (Nigeria)A;A 26% A;G 49% G;G 25%
  • African ancestry (Southwest US)A;A 12% A;G 56% G;G 32%
  • Chinese (Denver)A;A 42% A;G 44% G;G 15%
  • Gujarati IndianA;A 27% A;G 48% G;G 26%
  • Luhya (Kenya)A;A 27% A;G 56% G;G 17%
  • Mexican ancestry (Los Angeles)A;A 28% A;G 45% G;G 28%
  • Maasai (Kenya)A;A 22% A;G 42% G;G 36%
  • TuscanA;A 2% A;G 34% G;G 64%

Other PVT1 SNPs

All PVT1 SNPs

Notes

From SNPedia

Notes

Study of 105 unrelated case subjects with ESRD and 102 controls with type 2 diabetes for > or =10 years without macroalbuminuria. Association observed for rs2648875 (OR 2.97 per A allele) diabetes.diabetesjournals.org

Source and license

Adapted from rs2648875 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.