rs2675703

A SNP in the OPN4 gene on chromosome 10. Its most notable genotype is C;C: common on affy axiom data

Gene
OPN4
Location
Chr 1086,654,812 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
9%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon on affy axiom dataTypical · 0.083% of people
  2. T;TNot rated5.6x more likely to have seasonal affective disorder (SAD)Typical · 0.01% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 83% T;T 1%
  • European ancestry (Utah)C;C 73% T;T 3%
  • Han Chinese (Beijing)C;C 96% T;T <1%
  • Japanese (Tokyo)C;C 87% T;T 0%
  • Yoruba (Nigeria)C;C 96% T;T 0%
  • African ancestry (Southwest US)C;C 91% T;T 2%
  • Chinese (Denver)C;C 93% T;T 0%
  • Gujarati IndianC;C 80% T;T 1%
  • Luhya (Kenya)C;C 92% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 74% T;T 5%
  • Maasai (Kenya)C;C 76% T;T 1%
  • TuscanC;C 61% T;T 3%

Conditions, medicines and genes

Notes

From SNPedia

Notes

T;T

This SNP in the melanopsin OPN4 gene is associated with seasonal affective disorder, according to one study with 130 affected participants. PMID 18804284

References

Source and license

Adapted from rs2675703 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.