rs267606861

A SNP in the HDC gene on chromosome 15. Its most notable genotype is T;T: Tourette Syndrome mutation

Gene
HDC
Location
Chr 1550,252,520 (GRCh38)
Highest magnitude
6.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadTourette Syndrome mutationVery important · 6.0
  2. C;TBadTourette Syndrome mutationVery important · 6.0
  3. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs267606861 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other HDC SNPs

All HDC SNPs

Notes

From SNPedia

Notes

rs267606861, also known as c.951G>A, p.Trp317Ter and W317X, is a mutation in the HDC gene on chromosome 15. The HDC gene encodes L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis. Mutations leading to Tourette syndrome have been quite hard to find, and so far, there is only one mutation known: rs267606861(A). This very rare allele is reported to act as an autosomal dominant mutation, based on an analysis of a two-generation pedigree. See also OMIM 142704.0001

T;T

see discussion at rs267606861

C;T

see discussion at rs267606861

Source and license

Adapted from rs267606861 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.