rs2708377

A SNP in the PRH1-TAS2R14 gene on chromosome 12. Its most notable genotype is T;T: Less sensitive to bitter taste of Caffeine

Gene
PRH1-TAS2R14
Location
Chr 1211,063,716 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedLess sensitive to bitter taste of CaffeineTypical · 0.060% of people
  2. C;TNot ratedNo summary available.Typical · 0.030% of people
  3. C;CNot ratedMore sensitive to bitter taste of CaffeineTypical · 0.010% of people

SNPedia records rs2708377 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 60% C;T 30% C;C 10%
  • European ancestry (Utah)T;T 73% C;T 27% C;C 0%
  • Han Chinese (Beijing)T;T 92% C;T 8% C;C 0%
  • Japanese (Tokyo)T;T 92% C;T 8% C;C 0%
  • Yoruba (Nigeria)T;T 14% C;T 57% C;C 29%
  • African ancestry (Southwest US)T;T 30% C;T 53% C;C 18%
  • Chinese (Denver)T;T 90% C;T 9% C;C <1%
  • Gujarati IndianT;T 71% C;T 27% C;C 2%
  • Luhya (Kenya)T;T 11% C;T 50% C;C 39%
  • Mexican ancestry (Los Angeles)T;T 83% C;T 17% C;C 0%
  • Maasai (Kenya)T;T 30% C;T 52% C;C 18%
  • TuscanT;T 74% C;T 26% C;C 1%

Notes

From SNPedia

Notes

C;T

More sensitive to bitter taste of Caffeine

Source and license

Adapted from rs2708377 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.