rs27388

A SNP in the MEGF10 gene on chromosome 5. Its most notable genotype is A;A: Increased risk of developing schizophrenia

Gene
MEGF10
Location
Chr 5127,348,117 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadIncreased risk of developing schizophreniaWorth knowing · 2.025% of people
  2. A;GBadSlightly increased risk of developing schizophreniaMinor · 1.550% of people
  3. G;GGoodNormal risk of developing schizophreniaMinor · 1.025% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 25% A;G 50% G;G 25%
  • European ancestry (Utah)A;A 32% A;G 56% G;G 12%
  • Han Chinese (Beijing)A;A 15% A;G 55% G;G 30%
  • Japanese (Tokyo)A;A 22% A;G 44% G;G 34%
  • Yoruba (Nigeria)A;A 27% A;G 50% G;G 24%
  • African ancestry (Southwest US)A;A 21% A;G 55% G;G 23%
  • Chinese (Denver)A;A 11% A;G 51% G;G 38%
  • Gujarati IndianA;A 18% A;G 52% G;G 30%
  • Luhya (Kenya)A;A 42% A;G 41% G;G 17%
  • Mexican ancestry (Los Angeles)A;A 14% A;G 56% G;G 30%
  • Maasai (Kenya)A;A 33% A;G 50% G;G 17%
  • TuscanA;A 36% A;G 44% G;G 21%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs27388 is a SNP in the MEGF10 gene. In a case-control study involving 652 Irish patients, rs27388(A) allele carriers were at increased risk for schizophrenia. (Note that the (A) allele is quite common in many populations.) No association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample.

Source and license

Adapted from rs27388 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.