rs2814707

A SNP in the LOC107987057 gene on chromosome 9. Its most notable genotype is T;T: >1.2x increased risk for ALS

Gene
LOC107987057
Location
Chr 927,536,399 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
18%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad>1.2x increased risk for ALSMinor · 1.23% of people
  2. C;TBad1.2x increased risk for ALSMinor · 1.224% of people
  3. C;CGoodnormalTypical · 0.072% of people

SNPedia records rs2814707 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 3% C;T 24% C;C 72%
  • European ancestry (Utah)T;T 10% C;T 28% C;C 62%
  • Han Chinese (Beijing)T;T <1% C;T 10% C;C 90%
  • Japanese (Tokyo)T;T 0% C;T 12% C;C 89%
  • Yoruba (Nigeria)T;T 3% C;T 32% C;C 65%
  • African ancestry (Southwest US)T;T 5% C;T 28% C;C 67%
  • Chinese (Denver)T;T 0% C;T 11% C;C 89%
  • Gujarati IndianT;T 1% C;T 25% C;C 74%
  • Luhya (Kenya)T;T 4% C;T 36% C;C 60%
  • Mexican ancestry (Los Angeles)T;T 2% C;T 5% C;C 93%
  • Maasai (Kenya)T;T 4% C;T 35% C;C 62%
  • TuscanT;T 9% C;T 43% C;C 48%

Other LOC107987057 SNPs

All LOC107987057 SNPs

Notes

From SNPedia

Notes

rs2814707 is one of 2 SNPs from the ch 9p21.2 region associated in a large GWAS study with ALS risk, the other SNP being rs3849942. In this study, the reported odds ratio for rs2814707(A) was 1.22 (CI: 1.15 - 1.30, p = 4.72 x 10e-10). The odds ratio for the minor rs2814707(A) allele was 1.16 (p=7.45x10e-9). 23andMe blog rs2814707(T) 1.16x odds of ALS rs12608932(C) 1.2x odds of ALS

Source and license

Adapted from rs2814707 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.