rs2823256

A SNP in the LOC101927745 gene on chromosome 21. Its most notable genotype is A;A: normal risk of Crohn's disease in Koreans

Gene
LOC101927745
Location
Chr 2115,412,387 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormal risk of Crohn's disease in KoreansTypical · 0.08% of people
  2. A;GBad1.35x increased risk of Crohn's disease in KoreansTypical · 0.040% of people
  3. G;GBad>1.32x increased risk of Crohn's disease in KoreansTypical · 0.053% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 8% A;G 40% G;G 53%
  • European ancestry (Utah)A;A 9% A;G 44% G;G 47%
  • Han Chinese (Beijing)A;A 10% A;G 39% G;G 51%
  • Japanese (Tokyo)A;A 7% A;G 43% G;G 50%
  • Yoruba (Nigeria)A;A 3% A;G 25% G;G 73%
  • African ancestry (Southwest US)A;A 2% A;G 35% G;G 63%
  • Chinese (Denver)A;A 17% A;G 43% G;G 41%
  • Gujarati IndianA;A 6% A;G 33% G;G 61%
  • Luhya (Kenya)A;A 8% A;G 42% G;G 50%
  • Mexican ancestry (Los Angeles)A;A 7% A;G 40% G;G 53%
  • Maasai (Kenya)A;A 10% A;G 51% G;G 39%
  • TuscanA;A 9% A;G 42% G;G 49%

Notes

From SNPedia

Notes

Implicated in a 2015 Korean cohort for Crohn's disease. PMID 25489960

Source and license

Adapted from rs2823256 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.