rs2828520

A SNP on chromosome 21. Its most notable genotype is G;G: 1.35x major depressive disorder risk

Gene
None listed
Location
Chr 2123,770,802 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;GBadHigher major depressive disorder risk ?Typical · 0.040% of people
  2. G;GMost notableBad1.35x major depressive disorder riskMinor · 1.111% of people

On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;G 40% G;G 11%
  • European ancestry (Utah)A;G 40% G;G 11%
  • Han Chinese (Beijing)A;G 29% G;G 3%
  • Japanese (Tokyo)A;G 33% G;G 4%
  • Yoruba (Nigeria)A;G 53% G;G 20%
  • African ancestry (Southwest US)A;G 40% G;G 12%
  • Chinese (Denver)A;G 27% G;G 2%
  • Gujarati IndianA;G 42% G;G 7%
  • Luhya (Kenya)A;G 48% G;G 24%
  • Mexican ancestry (Los Angeles)A;G 35% G;G 3%
  • Maasai (Kenya)A;G 47% G;G 20%
  • TuscanA;G 48% G;G 13%

Source and license

Adapted from rs2828520 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.