rs2832407

A SNP in the GRIK1 gene on chromosome 21. Its most notable genotype is C;C: topiramate may work to reduce heavy drinking best for this genotype

Gene
GRIK1
Location
Chr 2129,595,188 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedtopiramate may work to reduce heavy drinking best for this genotypeWorth knowing · 2.017% of people

On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 17%
  • European ancestry (Utah)C;C 35%
  • Han Chinese (Beijing)C;C 23%
  • Japanese (Tokyo)C;C 10%
  • Yoruba (Nigeria)C;C 0%
  • African ancestry (Southwest US)C;C 4%
  • Chinese (Denver)C;C 15%
  • Gujarati IndianC;C 25%
  • Luhya (Kenya)C;C 2%
  • Mexican ancestry (Los Angeles)C;C 19%
  • Maasai (Kenya)C;C 6%
  • TuscanC;C 47%

Conditions, medicines and genes

Other GRIK1 SNPs

All GRIK1 SNPs

Notes

From SNPedia

Notes

The rs2832407(C) allele has inconsistently been linked to alcoholism and its treatment. Nonetheless, a 2014 report based on 138 patients concludes that rs2832407(C;C) individuals show a greater decrease than non-carriers (of a rs2832407(C) allele) in the number of heavy drinking days per week when taking topiramate at a dose of 200 mg/daily. A follow-up study done 3 and 6 months after treatment seemed to mostly confirm the topiramate benefit preferentially to rs2832407(C;C) individuals.

C;C

Research by Dr. H. Kranzler's group has found that the drug topiramate was more effective in reducing heavy drinking in individuals with this rs2832407(C;C) genotype.

Source and license

Adapted from rs2832407 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.