rs2853499

A SNP in the ND5 gene on chromosome MT. Its most notable genotype is A;A: G12372A+, MT-Haplogroup U or K

Gene
ND5
Location
Chr MT12,372 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodG12372A+, MT-Haplogroup U or KMinor · 1.010% of people
  2. G;GGoodG12372A-, not MT-Haplogroup U or KTypical · 0.190% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 10% G;G 90%
  • European ancestry (Utah)A;A 25% G;G 75%
  • Han Chinese (Beijing)A;A 4% G;G 96%
  • Japanese (Tokyo)A;A 9% G;G 91%
  • Yoruba (Nigeria)A;A 0% G;G 100%

Other ND5 SNPs

All ND5 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

More commonly known as G12372A, or just 12372. One of the 3 SNPs that defines Mitochondrial Haplogroup U and its descendants.

A;A

Mitochondrial Haplogroup U or K. Harmless mitochondrial mutation, synonymous coding for same amino acid.

G;G

Normal healthy mitochondrial SNP. Not Mitochondrial Haplogroup U or K.

Source and license

Adapted from rs2853499 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.