rs2854464

A SNP in the ACVR1B gene on chromosome 12. Its most notable genotype is A;A: higher muscle strength

Gene
ACVR1B
Location
Chr 1251,995,107 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodhigher muscle strengthWorth knowing · 2.040% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 40%
  • European ancestry (Utah)A;A 60%
  • Han Chinese (Beijing)A;A 45%
  • Japanese (Tokyo)A;A 33%
  • Yoruba (Nigeria)A;A 22%
  • African ancestry (Southwest US)A;A 34%
  • Chinese (Denver)A;A 45%
  • Gujarati IndianA;A 58%
  • Luhya (Kenya)A;A 39%
  • Mexican ancestry (Los Angeles)A;A 12%
  • Maasai (Kenya)A;A 31%
  • TuscanA;A 61%

Notes

From SNPedia

Notes

A;A

the high muscle strength mutation at ACVR1B, specifically tested on the knees

Source and license

Adapted from rs2854464 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.