rs2854536

A SNP on chromosome 7. Its most notable genotype is A;A: Potential environmental trigger for autoimmune diseases

Gene
None listed
Location
Chr 7142,357,119 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;AMost notableBadPotential environmental trigger for autoimmune diseasesMinor · 1.033% of people

SNPedia records rs2854536 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 33%
  • European ancestry (Utah)A;A 5%
  • Han Chinese (Beijing)A;A 53%
  • Japanese (Tokyo)A;A 65%
  • Yoruba (Nigeria)A;A 34%
  • African ancestry (Southwest US)A;A 23%
  • Chinese (Denver)A;A 58%
  • Gujarati IndianA;A 42%
  • Luhya (Kenya)A;A 20%
  • Mexican ancestry (Los Angeles)A;A 35%
  • Maasai (Kenya)A;A 22%
  • TuscanA;A 13%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 170 words

A 2013 study of ~1,000+ Chinese patients with narcolepsy concluded that the common rs2854536(T) allele had a slight association with the condition. As stated in the article: "Narcolepsy-hypocretin deficiency results from a highly specific autoimmune attack on hypocretin cells.... Recent studies have established antigen presentation by specific class II proteins encoded by (HLA DQB1*06:02 and DQA1*01:02) to the cognate T cell receptor as the main disease pathway, with a role for H1N1 influenza in the triggering process.... We also identified differences in HLA haplotype frequencies among cases with onset following the 2009 H1N1 influenza pandemic as compared to before the outbreak, with fewer HLA DQB1*06:02 homozygotes.... This may be the first demonstration of such an effect, and suggests that the study of changes in GWAS signals over time could help identify environmental factors in other autoimmune diseases."

A;A

See text on main rs-page; note genotype is a very common one, especially among Asians

Source and license

Adapted from rs2854536 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.