rs2854747

A SNP in the IGFBP3 gene on chromosome 7. Its most notable genotype is G;G: 2326.08ng/mL of IGFBP-3 in plasma

Gene
IGFBP3
Location
Chr 745,920,318 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
39%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated2326.08ng/mL of IGFBP-3 in plasmaMinor · 1.0100% of people
  2. A;GNot rated2659.70ng/mL of IGFBP-3 in plasmaMinor · 1.00% of people
  3. A;ANot rated2743.02ng/mL of IGFBP-3 in plasmaMinor · 1.00% of people

SNPedia records rs2854747 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 100% A;G 0% A;A 0%
  • European ancestry (Utah)G;G 100% A;G 0% A;A 0%
  • Han Chinese (Beijing)G;G 100% A;G 0% A;A 0%
  • Japanese (Tokyo)G;G 100% A;G 0% A;A 0%
  • Yoruba (Nigeria)G;G 100% A;G 0% A;A 0%

Notes

From SNPedia

Show notes, about 230 words

Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.

G;G

Lowest Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) levels in plasma. The geometric mean (average) amount of IGFBP-3 in blood plasma for people with this SNP is 2326.08 ng/mL (for all races). 95% of people with this are in the range 2205.86ng/mL to 2452.85ng/mL, meaning even someone with the highest levels is still lower in IGFBP3 than the lowest individual with other versions of this SNP.

A;G

The geometric mean (average) amount of Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) in blood plasma for people with this SNP is 2659.70 ng/mL (for all races). 95% of people with this are in the range 2565.40ng/mL to 2757.47ng/mL. For specific races/ethnicities: Hispanic: 2455.07 (2272.48, 2652.32); Japanese: 2479.48 (2226.29, 2761.46); African-American: 2719.46 (2518.32 to 2936.66); White: 2759.05 (2543, 2993.45); Native Hawaiian: 2832.8 (2619.88, 3063.01).

A;A

Highest Insulin-like Growth Factor Binding Protein 3 (IGFBP-3) levels in plasma. The geometric mean (average) amount of IGFBP-3 in blood plasma for people with this SNP is 2743.02 nanograms per milliliter (for all races). 95% of people with this are in the range 2635.04ng/mL to 2855.43ng/mL.

References

Source and license

Adapted from rs2854747 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.