rs28929474(C;T)

Carrier for Alpha-1 Antitrypsin Deficiency

Magnitude
3.0Important
Repute
Bad
On SNPedia
rs28929474(A;G)Minus strand
Gene
SERPINA1

Other genotypes of rs28929474

  1. T;TMost notableBadAlpha-1 Antitrypsin DeficiencyVery important · 5.5
  2. C;CGoodcommon in complete genomicsTypical · 0.0

All about rs28929474

Notes

From SNPedia

1 copy of the PI*Z allele, the most common cause of Alpha-1 Antitrypsin Deficiency; likely to be unaffected unless also carrying a PiS allele. This has been associated with Wegener's Granulomatosis / Granulomatosis with Polyangiitis, a type of Vasculitis. It has also been suggested in small studies that vasculitis may be more severe in patients positive for PiZ allele. A higher prevalence of the PiZ Allele has also been noted in some small studies of ANCA positive ulcerative colitis.

References

Source and license

Adapted from rs28929474(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.