rs28934574

A SNP in the TP53 gene on chromosome 17. Its most notable genotype is C;G: Li-Fraumeni Syndrome (predicted)

Gene
TP53
Location
Chr 177,673,776 (GRCh38)
Highest magnitude
7.0Very important
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon in clinvarTypical · 0.0
  2. C;GMost notableBadLi-Fraumeni Syndrome (predicted)Very important · 7.0
  3. A;GBadpossible association with Li-Fraumeni-like syndromeImportant · 3.5
  4. C;CNot ratedNo summary available.Typical · 0.0

SNPedia records rs28934574 on the minus strand: (C;C), (C;G), (C;T), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other TP53 SNPs

All TP53 SNPs

Notes

From SNPedia

Notes

rs28934574, also known as Arg282Trp or R282W, is a SNP in the p53 TP53 tumor suppressor gene. The rare rs28934574(T) allele is associated with predisposition to cancer in the form of a condition denoted Li-Fraumeni syndrome-like in OMIM. However, there is conflicting evidence in ClinVar as to whether this really is a pathogenic (causal) variant; some submitters indicate is benign while others say it is indeed pathogenic. See also OMIM 191170.0018 This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.

A;G

see discussion at rs28934574

Source and license

Adapted from rs28934574 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.