rs28934578(C;T)

Li-Fraumeni syndrome?? (an inherited cancer predisposition - but see note below)

Magnitude
4.0Very important
Repute
Bad
On SNPedia
rs28934578(A;G)Minus strand
Gene
TP53

Other genotypes of rs28934578

  1. T;TMost notableBadinfo@snpedia.com would like to hear from youVery important · 8.0
  2. C;CGoodcommon in clinvarTypical · 0.0

All about rs28934578

Notes

From SNPedia

This genotype is associated with Li Fraumeni syndrome. However, we have noticed a statistically unlikely increase in the number of customers of one DNA testing company who's genotype for this SNP is being incorrectly reported. This is likely to be a technical error - you probably actually carry the completely normal, unmutated genotype for this SNP. You should seek to have a clinically validated test carried out if you have either a significant family history of cancer or if you have any concerns about this. See https://www.reddit.com/r/23andme/comments/2xit8m/how_does_one_interpret_significance/

Source and license

Adapted from rs28934578(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.