rs2943641

A SNP on chromosome 2. Its most notable genotype is C;C: increased risk for type 2 diabetes

Gene
None listed
Location
Chr 2226,229,029 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadincreased risk for type 2 diabetesTypical · 0.057% of people
  2. C;TNot ratedincreased risk for type 2 diabetesTypical · 0.036% of people

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 57% C;T 36%
  • European ancestry (Utah)C;C 42% C;T 43%
  • Han Chinese (Beijing)C;C 89% C;T 11%
  • Japanese (Tokyo)C;C 87% C;T 13%
  • Yoruba (Nigeria)C;C 57% C;T 39%
  • African ancestry (Southwest US)C;C 47% C;T 47%
  • Chinese (Denver)C;C 89% C;T 11%
  • Gujarati IndianC;C 54% C;T 41%
  • Luhya (Kenya)C;C 32% C;T 52%
  • Mexican ancestry (Los Angeles)C;C 64% C;T 35%
  • Maasai (Kenya)C;C 34% C;T 51%
  • TuscanC;C 36% C;T 51%

Notes

From SNPedia

Notes

identified a significant association of rs2943641 near IRS1 locus, with type 2 diabetes in the Japanese population. Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus. The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects. Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

Source and license

Adapted from rs2943641 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.