rs2952768

A SNP on chromosome 2. Its most notable genotype is C;C: less drug dependence, decreased effectiveness of analgesics

Gene
None listed
Location
Chr 2207,629,510 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodless drug dependence, decreased effectiveness of analgesicsMinor · 1.014% of people
  2. C;TGoodslightly less drug dependence, decreased effectiveness of analgesicsMinor · 1.044% of people
  3. T;TBadnormal/slightly increased risk of drug dependence, normal effectiveness of analgesicsMinor · 1.042% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 14% C;T 44% T;T 42%
  • European ancestry (Utah)C;C 14% C;T 49% T;T 38%
  • Han Chinese (Beijing)C;C 16% C;T 47% T;T 37%
  • Japanese (Tokyo)C;C 12% C;T 41% T;T 47%
  • Yoruba (Nigeria)C;C 7% C;T 39% T;T 54%
  • African ancestry (Southwest US)C;C 9% C;T 40% T;T 51%
  • Chinese (Denver)C;C 11% C;T 53% T;T 36%
  • Gujarati IndianC;C 24% C;T 48% T;T 28%
  • Luhya (Kenya)C;C 17% C;T 44% T;T 39%
  • Mexican ancestry (Los Angeles)C;C 21% C;T 33% T;T 47%
  • Maasai (Kenya)C;C 8% C;T 51% T;T 41%
  • TuscanC;C 12% C;T 42% T;T 46%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 140 words

Genome-wide association study identifies a potent locus associated with human opioid sensitivity rs2952768(C) was associated with more analgesic requirements ... exhibited less vulnerability to severe methamphetamine or alcohol dependence, fewer eating disorders, and a lower ‘Reward Dependence’ score on a personality questionnaire. The (C;C) genotype was significantly associated with the elevated expression of a neighboring gene, CREB1. SNPs in this locus are the most potent genetic factors associated with human opioid sensitivity known to date, affecting both the efficacy of opioid analgesics such as morphine and fentanyl and liability to severe substance dependence. These findings may provide valuable information for the personalized treatment of pain and drug dependence. Other related opioids include buprenorphine, meperidine and pentazocine.

Source and license

Adapted from rs2952768 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.